联合使用干扰素、泛昔洛韦和粒细胞巨噬细胞集落刺激因子治疗一名结节性多动脉炎患者的乙肝病毒感染。

Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa.

作者信息

Molloy P J, Friedlander L, Van Thiel D H, Kania R J

机构信息

Keystone Digestive Disease Consultants, Pittsburgh, USA.

出版信息

Hepatogastroenterology. 1999 Jul-Aug;46(28):2529-31.

PMID:10522033

Abstract

Treatment of chronic hepatitis B virus (HBV) infection in an individual with periarteritis nodosum is described. A combination of famciclovir, granulocyte macrophage colony stimulating factor (GM-CSF) and interferon alpha 2b was utilized. The periarteritis, but not the HBV infection, responded to immunosuppressive therapy consisting of cyclophosphamide and glucocorticoids. Moreover, the patient failed to clear this HBV infection, despite a full year of interferon therapy at 5 MU daily. With the addition of famciclovir and GM-CSF, the HBV infection rapidly resolved and he converted from HBsAg and eAg positive to HBsAb and eAb positive. No exacerbation of his periarteritis nodosum occurred during the course of his antiviral therapy.

摘要

描述了对一名患有结节性多动脉炎的个体进行慢性乙型肝炎病毒（HBV）感染治疗的情况。使用了泛昔洛韦、粒细胞巨噬细胞集落刺激因子（GM-CSF）和干扰素α2b的联合治疗。结节性多动脉炎对由环磷酰胺和糖皮质激素组成的免疫抑制治疗有反应，但HBV感染无反应。此外，尽管患者接受了为期一整年的每日5 MU干扰素治疗，但仍未能清除HBV感染。加入泛昔洛韦和GM-CSF后，HBV感染迅速得到解决，他从HBsAg和eAg阳性转为HBsAb和eAb阳性。在抗病毒治疗过程中，他的结节性多动脉炎没有加重。