Kumar G R, Reddy K P
Department of Zoology, Osmania University, Hyderabad, India.
Indian J Exp Biol. 1999 Jul;37(7):662-6.
Administration of ethanol (95%) extract (45 mg/kg body wt/day for 28 days) of garlic (A. sativum) to alloxan induced diabetic (ALX-D) mice significantly lowered the serum glucose levels, nociceptive response in tail-flick, hotplate, allodynia, formalin test and relative thickness, weight of hind paw in formalin induced Paw oedema test, over 28 days, thus, showing the reversal trend in hyperglycemia and hyperalgesia compared to ALX-D mice. The reversal of hyperglycemia and hyperalgesia was progressive and more effective as duration of extract administration increased. The results suggest therapeutic potential of ethanol extract of garlic for anti-hyperglycemic and anti-nociceptive effects in diabetes.
给四氧嘧啶诱导的糖尿病（ALX-D）小鼠灌胃大蒜（大蒜）乙醇（95%）提取物（45毫克/千克体重/天，持续28天），在28天内显著降低了血清葡萄糖水平、甩尾、热板、痛觉过敏、福尔马林试验中的伤害性反应以及福尔马林诱导的爪肿胀试验中后爪的相对厚度和重量，因此，与ALX-D小鼠相比，显示出高血糖和痛觉过敏的逆转趋势。高血糖和痛觉过敏的逆转是渐进的，并且随着提取物给药时间的延长效果更显著。结果表明大蒜乙醇提取物在糖尿病中具有抗高血糖和抗伤害感受作用的治疗潜力。
