Oberseider J, Felten-Keil G, Schuler K, Goebels N, Hamann G F
Neurologische Klinik, Ludwig-Maximilians Universität, München.
Ultraschall Med. 1999 Aug;20(4):144-9. doi: 10.1055/s-1999-8902.
The purpose of this study was to investigate the degree of atherosclerosis in patients with stenoses or occlusions in the vertebrobasilar system (VBS) and the carotid system (CS).
The Intima-Media-Thickness (IMT) and the diameter of the common carotid artery (CCA) (as parameters of the proliferative and dilatative form of atherosclerosis) were measured on both sides on areas of vessel wall without stenoses and plaques. We examined of the neck 134 people, including 32 normal healthy counds, 57 patients with stenoses or occlusions in the CS and 16 patients with macroangiopathy exclusively in the VBS (following doppler- and duplex sonographical criteria).
In control persons, a IMT of 0.67 +/- 0.2 mm and a CCA-diameter of 5.8 +/- 1.2 mm was found. Patients with CS-macroangiopathy exhibited a statistically significant increase in IMT with 0.97 +/- 0.2 mm (p < 0.001) and dilatation of the CCA (6.6 +/- 1.2 mm, p < 0.01). In comparison to the controls we also found a significant increase in IMT (0.86 +/- 0.2 mm, p < 0.001) and in diameter (6.8 +/- 0.9 mm, p < 0.01) in patients with VBS-macroangiopathy. There was no significant difference between both groups, despite a tendency of less severe changes in patients suffering from VBS-macroangiopathy. Patients with diabetes (1.1 +/- 0.2 mm, p < 0.001), with hypertension (0.99 +/- 0.2 mm, p < 0.05) and with coronary heart disease (0.96 +/- 0.2 mm, p < 0.05) showed a significant increase in IMT.
Parameters of generalized atherosclerosis do not significantly differ between patients with stenoses or occlusions in the VBS and patients with changes in the CS and are correlated to the classical risk factors.
本研究旨在调查椎基底动脉系统（VBS）和颈动脉系统（CS）存在狭窄或闭塞的患者的动脉粥样硬化程度。
在无狭窄和斑块的血管壁区域双侧测量颈总动脉（CCA）的内膜中层厚度（IMT）和直径（作为动脉粥样硬化增殖和扩张形式的参数）。我们检查了134人的颈部，包括32名正常健康对照者、57名CS存在狭窄或闭塞的患者以及16名仅VBS存在大血管病变的患者（根据多普勒和双功超声检查标准）。
在对照者中，发现IMT为0.67±0.2毫米，CCA直径为5.8±1.2毫米。CS大血管病变患者的IMT有统计学显著增加，为0.97±0.2毫米（p<0.001），且CCA扩张（6.6±1.2毫米，p<0.01）。与对照组相比，VBS大血管病变患者的IMT（0.86±0.2毫米，p<0.001）和直径（6.8±0.9毫米，p<0.01）也有显著增加。两组之间无显著差异，尽管VBS大血管病变患者的变化趋势较轻。糖尿病患者（1.1±0.2毫米，p<0.001）、高血压患者（0.99±0.2毫米，p<0.05）和冠心病患者（0.96±0.2毫米，p<0.05）的IMT显著增加。
VBS存在狭窄或闭塞的患者与CS存在病变的患者之间，全身性动脉粥样硬化参数无显著差异，且与经典危险因素相关。
