1-芳基-3-取代吡咯并[3,2-c]喹啉的合成及药理特性
Synthesis and pharmacological profile of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines.
作者信息
Yum E K, Kang S K, Kim S S, Choi J K, Cheon H G
机构信息
Korea Research Institute of Chemical Technology, Yusung, Taejon.
出版信息
Bioorg Med Chem Lett. 1999 Oct 4;9(19):2819-22. doi: 10.1016/s0960-894x(99)00496-5.
Abstract
A series of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines were synthesized and evaluated for their anti-ulcer activity. While 3-substituents of pyrrolo[3,2-c]quinolines mostly affected the in vitro H+/K+ ATPase activity, 1-aryl substituents of pyrrolo[3,2-c]quinolines affected the in vivo gastric acid secretion. In addition, the compounds with good in vivo activity protected from ethanol-induced ulcer.
摘要
合成了一系列1-芳基-3-取代的吡咯并[3,2-c]喹啉，并对其抗溃疡活性进行了评估。虽然吡咯并[3,2-c]喹啉的3-取代基主要影响体外H+/K+ ATP酶活性，但吡咯并[3,2-c]喹啉的1-芳基取代基影响体内胃酸分泌。此外，具有良好体内活性的化合物对乙醇诱导的溃疡具有保护作用。
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