复杂性状的基因定位

Genetic mapping of complex traits.

作者信息

Olson J M, Witte J S, Elston R C

机构信息

Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA.

出版信息

Stat Med. 1999 Nov 15;18(21):2961-81. doi: 10.1002/(sici)1097-0258(19991115)18:21<2961::aid-sim206>3.0.co;2-u.

DOI:10.1002/(sici)1097-0258(19991115)18:21<2961::aid-sim206>3.0.co;2-u

PMID:10523753

Abstract

Statistical genetic mapping methods are powerful tools for finding genes that contribute to complex human traits. Mapping methods combine knowledge of the biological mechanisms of inheritance and the randomness inherent in those mechanisms to locate, with increasing precision, trait genes on the human genome. We provide an overview of the two major classes of mapping methods, genetic linkage analysis and linkage disequilibrium analysis, and related concepts of genetic inheritance.

摘要

统计遗传图谱绘制方法是寻找导致复杂人类性状的基因的有力工具。图谱绘制方法结合了遗传生物学机制的知识以及这些机制中固有的随机性，从而在人类基因组上越来越精确地定位性状基因。我们概述了两类主要的图谱绘制方法，即遗传连锁分析和连锁不平衡分析，以及遗传遗传的相关概念。