Hu Zhong-Li, Dong Wei-Guo, Song Yun-Chun
Key Laboratory of MOE for Developmental Biology, Wuhan University, Wuhan 430072, China.
Yi Chuan Xue Bao. 2002 Feb;29(2):101-4.
Some genes controlling human diseases have been located on the regions less than 1 cM using linkage disequilibrium, and a few of them have been cloned. Z. W. Luo developed a method that can detect and estimate the coefficient of linkage disequilibrium between a marker locus and quantitative trait locus (QTL), and raised the theoretical strategies for high-resolution mapping of complex genetic disorders in humans. Based on the data mentioned above, a method for linkage test between a marker locus and QTL was set up, and a method for linkage test between two marker loci and epistatic QTL was suggested for the first time.
一些控制人类疾病的基因已通过连锁不平衡定位到小于1厘摩的区域，其中少数已被克隆。罗正伟开发了一种方法，可检测和估计标记位点与数量性状位点（QTL）之间的连锁不平衡系数，并提出了人类复杂遗传疾病高分辨率定位的理论策略。基于上述数据，建立了一种标记位点与QTL之间的连锁检验方法，并首次提出了两个标记位点与上位性QTL之间的连锁检验方法。
