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[创伤后葡萄膜炎的临床与免疫形态学相似之处]

[Clinical and immunomorphological parallels in posttraumatic uveitis].

作者信息

Arkhipova L T, Khoroshilova-Maslova I P, Kuznetsova I A, Iluridze S L

出版信息

Vestn Oftalmol. 1999 Jul-Aug;115(4):17-9.

Abstract

Parallels between the clinical diagnosis, immunological parameters of the leukocyte migration inhibition test (LMIT) to eye tissue antigens (uveoretinal, lenticular, and retinal), and morphological picture are studied in patients with posttraumatic uveitis and consequences of grave penetrating injuries to the eye without uveitis symptoms. Cell sensitization to uveoretinal antigen is detected only in posttraumatic uveitis but not in consequences of injuries without uveitis. The authors come to a conclusion that only positive LMIT with uveoretinal or a combination of uveoretinal and lenticular antigens may be considered as an immunological validation of autoimmune posttraumatic uveitis. Further improvement of LMIT with purified fractions of uveoretinal antigens is needed.

摘要

对创伤后葡萄膜炎患者以及无葡萄膜炎症状的严重眼球穿透伤后果进行了研究,探讨了临床诊断、针对眼组织抗原(葡萄膜视网膜、晶状体和视网膜)的白细胞迁移抑制试验(LMIT)的免疫参数与形态学表现之间的平行关系。仅在创伤后葡萄膜炎中检测到对葡萄膜视网膜抗原的细胞致敏,而在无葡萄膜炎的损伤后果中未检测到。作者得出结论,只有对葡萄膜视网膜抗原或葡萄膜视网膜与晶状体抗原组合的LMIT呈阳性,才可被视为自身免疫性创伤后葡萄膜炎的免疫学验证。需要进一步改进使用纯化的葡萄膜视网膜抗原组分的LMIT。

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