Paterson A D, Rahman P, Petronis A
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario, Canada.
Hum Immunol. 1999 Sep;60(9):883-5. doi: 10.1016/s0198-8859(99)00048-8.
Markers near a locus for type 1 diabetes on chromosome 3q22-q25 (IDDM9) demonstrate linkage to rheumatoid arthritis, however it is not clear whether these two loci overlap. Sex-specific linkage analysis may be of interest for rheumatoid arthritis on chromosome 3q since linkage of type 1 diabetes to IDDM9 derives predominantly from affected female sibpairs, and rheumatoid arthritis is more common in females than males. Using data from a recent genome scan for rheumatoid arthritis and sex-specific linkage analysis we show that linkage of rheumatoid arthritis to chromosome 3q peaks approximately 30 cM centromeric to IDDM9. Furthermore, there is no evidence for linkage to IDDM9 in females with rheumatoid arthritis.
位于3号染色体q22 - q25区域的1型糖尿病相关位点（IDDM9）附近的标记物显示与类风湿关节炎存在连锁关系，但尚不清楚这两个位点是否重叠。鉴于1型糖尿病与IDDM9的连锁主要源于患病女性同胞对，且类风湿关节炎在女性中比男性更常见，因此对3号染色体上类风湿关节炎进行性别特异性连锁分析可能会有意义。利用最近一项针对类风湿关节炎的全基因组扫描数据和性别特异性连锁分析，我们发现类风湿关节炎与3号染色体q区域的连锁峰值大约在IDDM9着丝粒方向30厘摩处。此外，没有证据表明患有类风湿关节炎的女性与IDDM9存在连锁关系。
