Antonijevic I A, Murck H, Frieboes R, Holsboer F, Steiger A
Max Planck Institute of Psychiatry, Munich, Germany.
Neuroendocrinology. 1999 Oct;70(4):280-7. doi: 10.1159/000054487.
Sleep-endocrine regulation in humans involves high activity of the somatotropic axis at the beginning of the night and an increase in the hypothalamic-pituitary-adrenocortical (HPA) system during the night. Gender differences were examined with regard to sleep-endocrine regulation in young healthy controls (10 men, 9 women). The sleep EEG was recorded (23:00-07:00 h) and plasma samples were collected and analyzed for GH, cortisol and ACTH at 20-min intervals. Cortisol secretion was significantly higher in females during the first half of the night (F = 9.9, p < 0.05), while ACTH was not different. In women, sleep-EEG analysis showed less slow wave sleep (SWS) during the second half of the night (F = 4.5, p < 0.05) and a significantly greater decrease in SWS and delta activity from the first to the second half of the night (F = 3.7 and 7.4, respectively, p < 0.05). Sigma activity increased during the night in women only (F = 3.7, p < 0.05). Our data are compatible with the hypothesis that in women compared to men activity of hypothalamic CRH neurons and central CRH release is greater, but is not reflected by greater HPA activity.
人类的睡眠-内分泌调节在夜间开始时涉及生长激素轴的高活性以及夜间下丘脑-垂体-肾上腺皮质（HPA）系统的增强。研究了年轻健康对照者（10名男性，9名女性）在睡眠-内分泌调节方面的性别差异。记录睡眠脑电图（23:00 - 07:00时），并每隔20分钟采集血浆样本，分析其中的生长激素（GH）、皮质醇和促肾上腺皮质激素（ACTH）。女性在前半夜的皮质醇分泌显著更高（F = 9.9，p < 0.05），而促肾上腺皮质激素没有差异。在女性中，睡眠脑电图分析显示后半夜的慢波睡眠（SWS）较少（F = 4.5，p < 0.05），并且从夜间前半段到后半段，慢波睡眠和δ波活动的显著下降幅度更大（分别为F = 3.7和7.4，p < 0.05）。仅在女性中，夜间西格玛活动增加（F = 3.7，p < 0.05）。我们的数据与以下假设相符：与男性相比，女性下丘脑促肾上腺皮质激素释放激素（CRH）神经元的活性和中枢CRH释放量更大，但这并未通过更高的HPA活性体现出来。
