Salvini M, Gabrielli F
Arch Sci Biol (Bologna). 1976 Jan-Dec;60(1-4):1-35.
Experimental data about the chemistry and the biology of chromosomal proteins are reviewed. Paragraphs include: aminoacid sequential data and post-translational covalent modications of histones, histone chemical differences in different tissues of the same species and in homologous organs of different species, histone synthesis subcellular localization and its association with DNA synthesis, histone synthesis transcriptional and translational control, histone synthesis during meiosis, oogenesis and early embryogenesis. The possible role of histones as controllers of gene expression is discussed and a model of primary structure of chromatine is proposed. The "acidic proteins" data concern the high tissue eterogenity of these proteins and their role in the steroid-hormon-controlled gene expression. The possible role of acidic proteins as general controllers of gene expression in eucariotic cells is discussed.
本文综述了关于染色体蛋白质化学和生物学的实验数据。内容包括：组蛋白的氨基酸序列数据和翻译后共价修饰、同一物种不同组织以及不同物种同源器官中组蛋白的化学差异、组蛋白合成的亚细胞定位及其与DNA合成的关联、组蛋白合成的转录和翻译控制、减数分裂、卵子发生和早期胚胎发生过程中的组蛋白合成。文中讨论了组蛋白作为基因表达调控因子的可能作用，并提出了染色质一级结构模型。“酸性蛋白质”的数据涉及这些蛋白质的高度组织异质性及其在类固醇激素控制的基因表达中的作用。文中还讨论了酸性蛋白质作为真核细胞中基因表达一般调控因子的可能作用。
