Shapiro M, Johnson B, Witmer W, Elenitsas R
University of Pennsylvania Medical Center, Department of Dermatology, Philadelphia 19104, USA.
Am J Dermatopathol. 1999 Oct;21(5):462-7. doi: 10.1097/00000372-199910000-00011.
Nevus sebaceus (NS) of Jadassohn is usually a verrucous plaque on the scalp or face that arises secondary to disordered development of epithelial, pilar, sebaceous, and apocrine structures. The emergence of neoplasia is a late stage in the natural history of NS. Although most neoplastic proliferations are benign, several malignant tumors have arisen in this lesion. We describe the first case of a benign spiradenoma arising in an NS on the scalp in a 72-year-old Caucasian woman. Reexcision was recommended to prevent the development of a second neoplastic process and to avoid the rare occurrence of a malignant transformation of the existing neoplasia. The patient declined reexcision and remains under observation. The spectrum of tumors arising in NS are described and are categorized according to behavior. Syringocystadenoma papilliferum is the most commonly observed benign growth, whereas basal cell carcinoma is the most frequently seen malignant process. The signs of tumor development (benign or malignant) within an NS are reviewed, and treatment recommendations are provided. The clinical course of rare and unique aggressive neoplasms originating in NS is summarized.
Jadassohn皮脂腺痣（NS）通常是头皮或面部的疣状斑块，由上皮、毛囊、皮脂腺和顶泌汗腺结构发育紊乱继发形成。肿瘤形成是NS自然病程的晚期阶段。虽然大多数肿瘤性增殖是良性的，但该病变中也出现过几种恶性肿瘤。我们报道了首例发生于一名72岁白人女性头皮NS内的良性汗腺螺旋腺瘤。建议再次切除以防止第二个肿瘤性病变的发生，并避免现有肿瘤罕见的恶性转化。患者拒绝再次切除，仍在观察中。本文描述了NS中出现的肿瘤谱，并根据其行为进行了分类。乳头状汗腺囊腺瘤是最常见的良性生长，而基底细胞癌是最常出现的恶性病变。本文回顾了NS内肿瘤发展（良性或恶性）的征象，并提供了治疗建议。总结了起源于NS的罕见且独特的侵袭性肿瘤的临床病程。
