Negri S, Capitanio A, Pegorari E, Azzolini D, Sardo P
Servizio di Anatomia Patologica, Azienda Ospedaliera di Desenzano, BS.
Pathologica. 1999 Jun;91(3):179-83.
This study includes 33 cases of ductal carcinoma in situ and its aim is to detect and classify microcalcifications according to their appearance, mammographically, histologically and morphometrically. From the histological point of view, intraductal carcinomas are classified following the criteria proposed by Holland et al. The types of carcinoma examined reveal the presence of different microcalcifications. The calcifications associated with G1 carcinomas appear as highly compact morphometrically, fine or mainly so mammographically and laminated or mixed histologically; no granular calcifications are observed. On the other hand, calcifications associated with type G2 appear as coarse mammographically, granular histologically and scarcely compact morphometrically. Finally, G3 carcinomas mainly reveal by mammography vermicular calcifications (in a few cases associated with fine ones). Granular calcifications are predominant on histological examination while morphometry shows the poorest level of compactness.
本研究包括33例导管原位癌，其目的是根据微钙化在乳房X线摄影、组织学和形态计量学上的表现对其进行检测和分类。从组织学角度来看，导管内癌按照Holland等人提出的标准进行分类。所检查的癌类型显示出不同微钙化的存在。与G1级癌相关的钙化在形态计量学上表现为高度致密，在乳房X线摄影上细小或主要如此，在组织学上为层状或混合状；未观察到颗粒状钙化。另一方面，与G2级相关的钙化在乳房X线摄影上表现为粗大，在组织学上为颗粒状，在形态计量学上几乎不致密。最后，G3级癌在乳房X线摄影上主要显示蠕虫状钙化（少数情况下与细小钙化相关）。颗粒状钙化在组织学检查中占主导，而形态计量学显示致密程度最差。
