Kotlińska J, Biała G
Department of Pharmacodynamics, Medical University School, Lublin, Poland.
Pol J Pharmacol. 1999 Jul-Aug;51(4):323-30.
Effects of the novel NMDA/glycine receptor antagonist, L-701,324, on morphine- and cocaine-induced conditioned place preference (CPP) were examined in male Wistar rats. After determination of initial preference, animals were conditioned with morphine (5 mg/kg, i.p.) or cocaine (5 mg/kg, i.p.) for 3 conditioning trials, alone or in combination of these drugs with L-701,324 (2.5 mg/kg and 5 mg/kg, p.o.). L-701,324 prevented acquisition of the place preference produced by morphine and cocaine. Administration of L-701,324 on the test day attenuated the expression of morphine-induced CPP, whereas it had no effect on cocaine CPP. When L-701,324 was given alone it did not affect dependent variables (i.e. time spent in non-preferred compartment) suggesting that L-701,324 did not display any reinforcing properties by itself. Our current data suggest that glycine site on the NMDA receptor complex may be involved in the mediation of the rewarding effects of drugs of abuse.
在雄性Wistar大鼠中检测了新型N-甲基-D-天冬氨酸/甘氨酸受体拮抗剂L-701,324对吗啡和可卡因诱导的条件性位置偏爱（CPP）的影响。在确定初始偏爱后，动物接受吗啡（5毫克/千克，腹腔注射）或可卡因（5毫克/千克，腹腔注射）进行3次条件性试验，单独给药或这些药物与L-701,324（2.5毫克/千克和5毫克/千克，口服）联合给药。L-701,324可阻止吗啡和可卡因产生的位置偏爱形成。在测试当天给予L-701,324可减弱吗啡诱导的CPP的表达，而对可卡因诱导的CPP没有影响。单独给予L-701,324时，它不会影响相关变量（即在非偏爱隔室中花费的时间），这表明L-701,324本身不具有任何强化特性。我们目前的数据表明，N-甲基-D-天冬氨酸受体复合物上的甘氨酸位点可能参与了滥用药物奖赏效应的介导。
