两种快速重复经颅磁刺激方案对增强阿扑吗啡反应性的效果比较。

Comparison of effectiveness of two schedules of rapid transcranial magnetic stimulation on enhancement of responsiveness to apomorphine.

作者信息

Zyss T, Mamczarz J, Roman A, Vetulani J

机构信息

Department of Psychiatry, Collegium Medicum, Jagiellonian University, Kraków, Poland.

出版信息

Pol J Pharmacol. 1999 Jul-Aug;51(4):363-6.

PMID:10540969

Abstract

Locomotor response to apomorphine (0.5 mg/kg s.c.) was tested in rats pre-treated with multiple rapid transcranial magnetic stimulation (rTMS) or electroconvulsive shock (ECS). rTMS (B = 1.6T, f = 20 Hz, t = 300 s) was delivered 9 times during 18 days (group rTMS1, total number of stimulations 54,000) or 18 times during 18 days (group rTMS2, total number of stimulations 108,000); ECS (I = 150 mA, f = 50 Hz, t = 500 ms) was delivered 9 times at 48 h intervals. Apomorphine given 24 h after the last treatment induced hyperactivity that was significantly more pronounced in rats receiving ECS and rTMS. The effect was most pronounced for electroconvulsive treatment, the least in the rTMS1 group. The results indicate that an increase in the total number of impulses during the rTMS may increase the responsiveness of rats to dopaminergic stimulation to the level comparable with that induced by ECS.

摘要

在预先接受多次快速重复经颅磁刺激（rTMS）或电休克（ECS）处理的大鼠中，测试了对阿扑吗啡（0.5毫克/千克，皮下注射）的运动反应。rTMS（B = 1.6特斯拉，f = 20赫兹，t = 300秒）在18天内进行9次（rTMS1组，刺激总数54,000次）或在18天内进行18次（rTMS2组，刺激总数108,000次）；ECS（I = 150毫安，f = 50赫兹，t = 500毫秒）以48小时间隔进行9次。在最后一次处理后24小时给予阿扑吗啡会诱发多动，这在接受ECS和rTMS的大鼠中明显更明显。电休克治疗的效果最明显，rTMS1组中最不明显。结果表明，rTMS期间脉冲总数的增加可能会使大鼠对多巴胺能刺激的反应性提高到与ECS诱导的水平相当。