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对大鼠应用重复经颅磁刺激的条件可能会掩盖治疗效果。

Conditions of application of repeated transcranial magnetic stimulation to rats may mask the effects of the treatment.

作者信息

Michaluk J, Antkiewicz-Michaluk L, Vetulani J

机构信息

Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków.

出版信息

Pol J Pharmacol. 2001 Nov-Dec;53(6):685-7.

PMID:11985347
Abstract

Rats of sham repeated transcranial magnetic stimulation (rTMS) group, kept in noisy room and transiently immobilized (5 min) for 12 consecutive days, showed similar inhibition of body weight gain, increase in exploratory locomotor activity, and elevation of motor response to apomorphine as rats undergoing magnetic stimulation of the brain, and had only slightly lower response in apomorphine stereotypy. Some of the responses ascribed to antidepressant action of rTMS in animal experiment may be due to environmental conditions, and not alternating magnetic field passing the brain.

摘要

假重复经颅磁刺激(rTMS)组的大鼠,被置于嘈杂的房间,并连续12天每天短暂固定(5分钟),其体重增加受到的抑制、探索性运动活动的增加以及对阿扑吗啡运动反应的增强,与接受脑部磁刺激的大鼠相似,且在阿扑吗啡刻板行为方面的反应仅略低。在动物实验中,一些归因于rTMS抗抑郁作用的反应可能是由于环境条件,而非穿过大脑的交变磁场。

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Conditions of application of repeated transcranial magnetic stimulation to rats may mask the effects of the treatment.对大鼠应用重复经颅磁刺激的条件可能会掩盖治疗效果。
Pol J Pharmacol. 2001 Nov-Dec;53(6):685-7.
2
Comparison of effectiveness of two schedules of rapid transcranial magnetic stimulation on enhancement of responsiveness to apomorphine.两种快速重复经颅磁刺激方案对增强阿扑吗啡反应性的效果比较。
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Effect of "enriched environment" during development on adult rat behavior and response to the dopamine receptor agonist apomorphine.发育期间“丰富环境”对成年大鼠行为及对多巴胺受体激动剂阿扑吗啡反应的影响。
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[Repetitive transcranial magnetic stimulation in depression; stimulation of the brain in order to cure the psyche].[重复经颅磁刺激治疗抑郁症;刺激大脑以治愈精神疾病]
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The expression of locomotor sensitization to apomorphine is dependent on time interval between injection and testing.对阿扑吗啡的运动敏化表达取决于注射与测试之间的时间间隔。
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引用本文的文献

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Strain differences in the effect of rTMS on cortical expression of calcium-binding proteins in rats.rTMS 对大鼠皮质钙结合蛋白表达影响的应变差异。
Exp Brain Res. 2014 Feb;232(2):435-42. doi: 10.1007/s00221-013-3751-6. Epub 2013 Nov 8.
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Translational neuromodulation: approximating human transcranial magnetic stimulation protocols in rats.转化神经调节:在大鼠中模拟人类经颅磁刺激方案。
Neuromodulation. 2012 Jul;15(4):296-305. doi: 10.1111/j.1525-1403.2012.00482.x. Epub 2012 Jul 10.
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Theta-burst transcranial magnetic stimulation alters cortical inhibition.
经颅磁刺激θ爆发改变皮质抑制。
J Neurosci. 2011 Jan 26;31(4):1193-203. doi: 10.1523/JNEUROSCI.1379-10.2011.
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θ burst and conventional low-frequency rTMS differentially affect GABAergic neurotransmission in the rat cortex.θ 爆发和传统低频 rTMS 对大鼠皮层 GABA 能神经传递的影响不同。
Exp Brain Res. 2009 Dec;199(3-4):411-21. doi: 10.1007/s00221-009-1961-8.
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High- and low-frequency repetitive transcranial magnetic stimulation differentially activates c-Fos and zif268 protein expression in the rat brain.高频和低频重复经颅磁刺激对大鼠脑内c-Fos和zif268蛋白表达的激活作用存在差异。
Exp Brain Res. 2008 Jun;188(2):249-61. doi: 10.1007/s00221-008-1356-2. Epub 2008 Apr 2.