细胞对磷酸三钙的反应。

Cellular responses to whitlockite.

作者信息

Ryan L M, Cheung H S, LeGeros R Z, Kurup I V, Toth J, Westfall P R, McCarthy G M

机构信息

Department of Medicine, Division of Rheumatology, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, Wisconsin 53226, USA.

出版信息

Calcif Tissue Int. 1999 Nov;65(5):374-7. doi: 10.1007/s002239900716.

DOI:10.1007/s002239900716

PMID:10541763

Abstract

Whitlockite crystals have been observed in both degenerating and normal articular cartilages. To determine their potential for inducing cartilage degeneration, we studied their ability to induce mitogenesis and synthesis and secretion of metalloproteases in vitro. Whitlockite crystals were found to stimulate cell proliferation and to stimulate synthesis and secretion of stromelysin and collagenase. However, they were less stimulatory than crystals that contained calcium (Ca) and phosphate without magnesium substitution for Ca. Whitlockite crystals elicit biologic cellular responses that suggest potential pathogenicity in arthritis, but are less potent than Ca phosphate crystals without magnesium.

摘要

在退变和正常的关节软骨中均观察到了白磷钙石晶体。为了确定其诱导软骨退变的可能性，我们研究了其在体外诱导有丝分裂以及金属蛋白酶合成与分泌的能力。发现白磷钙石晶体可刺激细胞增殖，并刺激基质溶解素和胶原酶的合成与分泌。然而，与不含镁替代钙的钙（Ca）和磷酸盐晶体相比，它们的刺激作用较小。白磷钙石晶体引发的生物学细胞反应表明其在关节炎中具有潜在致病性，但比不含镁的磷酸钙晶体的致病性要弱。