Heusinkveld R S, Feen A E, Jones S E
Tumori. 1978 Nov-Dec;64(6):631-7. doi: 10.1177/030089167806400610.
Seven patients with advanced nodular sclerosing Hodgkin's disease who relapsed after initial intensive combination chemotherapy were selected for individualized pathologic restaging and comprehensive radiotherapy. One patient failed to respond completely to mantle-field irradiation and no further staging or radiotherapy was undertaken. Six other patients underwent staging laparotomy and received total nodal irradiation including prophylactic lung irradiation (5 cases) and hepatic irradiation (3 cases). Irradiation was well tolerated. Complete remission was achieved by 5 patients and 2 continue in remission 29+ and 32+ months after beginning of irradiation. Five of the 7 patients remain alive. This study indicates that comprehensive irradiation is a relatively well tolerated and effective treatment for carefully selected patients with advanced Hodgkin's disease who have relapsed after combination chemotherapy. For selected patients, pathologic restaging and comprehensive radiotherapy can be considered as an alternative to further chemotherapy.
七名晚期结节硬化型霍奇金淋巴瘤患者在初始强化联合化疗后复发，被选来进行个体化病理再分期和综合放疗。一名患者对斗篷野照射未完全缓解，未进行进一步分期或放疗。其他六名患者接受了分期剖腹探查术，并接受了全淋巴结照射，包括预防性肺部照射（5例）和肝脏照射（3例）。照射耐受性良好。5例患者实现完全缓解，2例在开始照射后29个多月和32个多月持续缓解。7例患者中有5例仍存活。本研究表明，对于精心挑选的、在联合化疗后复发的晚期霍奇金淋巴瘤患者，综合照射是一种耐受性相对良好且有效的治疗方法。对于选定的患者，病理再分期和综合放疗可被视为进一步化疗的替代方案。
