Obermüller-Jevic U C, Francz P I, Frank J, Flaccus A, Biesalski H K
Department of Biological Chemistry and Nutrition, University of Hohenheim, Fruwirthstrasse 12, D-70593, Stuttgart, Germany.
FEBS Lett. 1999 Oct 29;460(2):212-6. doi: 10.1016/s0014-5793(99)01342-3.
beta-Carotene has often been discussed as a means to reduce the risk of skin photodamage. We studied the antioxidative potential of beta-carotene in human skin fibroblasts exposed to ultraviolet A light. Surprisingly, we found a pro-oxidative effect of beta-carotene. Using the induction of haem oxygenase-1 as a marker for oxidative stress, we found a strong enhancement of gene expression by beta-carotene in ultraviolet A-irradiated cells. This effect was clearly suppressed by concomitant addition of vitamin E but only moderately by vitamin C. The results show that beta-carotene has pro-oxidative properties in human skin fibroblasts exposed to ultraviolet-A light.
β-胡萝卜素常被作为一种降低皮肤光损伤风险的手段进行讨论。我们研究了β-胡萝卜素在暴露于紫外线A的人皮肤成纤维细胞中的抗氧化潜力。令人惊讶的是，我们发现β-胡萝卜素具有促氧化作用。以血红素加氧酶-1的诱导作为氧化应激的标志物，我们发现β-胡萝卜素能强烈增强紫外线A照射细胞中的基因表达。同时添加维生素E可明显抑制这种作用，但维生素C只能适度抑制。结果表明，β-胡萝卜素在暴露于紫外线A的人皮肤成纤维细胞中具有促氧化特性。
