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[慢性便秘的病理生理学及新的治疗建议]

[Pathophysiology of chronic constipation and new therapy recommendation].

作者信息

Stelzner F, Hansen H

机构信息

Chirurgisches Zentrum, Universität Bonn.

出版信息

Zentralbl Chir. 1999;124(9):804-11.

PMID:10544486
Abstract

Three causes of constipation are known: Chagas' disease, congenital megacolon (Hirschsprung's disease) and continent obstipation. Those diseases are rare, they can be treated successfully by drugs, surgery or psychotherapy. More common is the idiopathic chronic constipation, observed manly in females. A frequent cause is the laxative abuse for many years. The possible etiologic factors are discussed. Based on the fact, that constipation never occurs in patients with a colostomy, reasons for the development of chronic idiopathic constipation are presumed in a disturbance in the distal colon and the anorectum. A possible explanation for the malfunction of defecation could be a different calibre between the usually tight pelvic colon and the wide rectum. In contrast to the apolar structure of the large bowel, the rectum shows a polar fibrous configuration. An additional disorder in the feedback mechanism between continence and defecation could impede the bowel passage. Because of these observations and thoughts, we performed a deep resection of the rectum in 18 patients instead of resecting the dilated and elongated colon. All patients operated that way experienced a major improvement of their bowel function. Postoperatively the bowel movements were regular and normal.

摘要

已知便秘有三个病因

恰加斯病、先天性巨结肠(赫希施普龙病)和节制性便秘。这些疾病较为罕见,可通过药物、手术或心理治疗成功治愈。更常见的是特发性慢性便秘,多见于女性。一个常见原因是多年滥用泻药。文中讨论了可能的病因。基于结肠造口术患者从不发生便秘这一事实,推测慢性特发性便秘的发病原因是远端结肠和直肠肛管功能紊乱。排便功能障碍的一个可能解释是,通常狭窄的盆腔结肠与宽阔的直肠之间管径不同。与大肠的无极性结构不同,直肠呈现极性纤维结构。节制与排便之间反馈机制的额外紊乱可能会阻碍肠道通过。基于这些观察和思考,我们对18例患者进行了直肠深部切除术,而非切除扩张延长的结肠。所有接受该手术的患者肠道功能均有显著改善。术后排便规律且正常。

相似文献

1
[Pathophysiology of chronic constipation and new therapy recommendation].[慢性便秘的病理生理学及新的治疗建议]
Zentralbl Chir. 1999;124(9):804-11.
2
[Pathophysiology of defecatory disturbance in the patient with Hirschsprung's disease and chronically constipated patients with simple megarectum].[先天性巨结肠症患者及单纯性巨直肠慢性便秘患者排便障碍的病理生理学]
Nihon Geka Gakkai Zasshi. 1985 Sep;86(9):1277-80.
3
Segmental colectomy in the management of colonic inertia.节段性结肠切除术在结肠无力症治疗中的应用
Am Surg. 1998 Aug;64(8):775-7.
4
Operative management of severe constipation.严重便秘的手术治疗
Am Surg. 1999 Dec;65(12):1117-21; discussion 1122-3.
5
[Megacolon and megarectum in adults. Abdominal proctectomy with colo-anal anastomosis].[成人巨结肠和巨直肠。经腹直肠切除术加结肠肛管吻合术]
Schweiz Med Wochenschr. 1998 Nov 7;128(45):1755-62.
6
[Surgically treatable chronic constipative defecation disorders. Indications, diagnosis and therapy].[可手术治疗的慢性便秘性排便障碍。适应证、诊断与治疗]
Kinderarztl Prax. 1993 Oct;61(7-8):250-7.
7
Colonic motility and functional assessment of the patients with anorectal malformations according to Krickenbeck consensus.根据克里肯贝克共识对肛门直肠畸形患者进行结肠动力和功能评估。
J Pediatr Surg. 2008 Oct;43(10):1839-43. doi: 10.1016/j.jpedsurg.2008.01.055.
8
[Two cases of chronic constipation in the adult: Hirschsprung disease and idiopathic megacolon].成人慢性便秘两例:先天性巨结肠和特发性巨结肠
Minerva Chir. 1993 Jun 30;48(12):699-703.
9
[Differential surgical treatment of idiopathic megadolichocolon in adults].[成人特发性巨结肠的差异性外科治疗]
Vestn Khir Im I I Grek. 2002;161(1):33-7.
10
Constipation in children.儿童便秘
Am Fam Physician. 1996 Aug;54(2):611-8, 627.

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