Cowan D H, Kouroupis G M, Leers W D
Can Med Assoc J. 1975 Mar 22;112(6):693-7.
Fifty-eight adult patients with acute leukemia were screened at the onset of the disease for hepatitis B antigen (HBSAg) in the serum, and during the course of the disease for the development of hepatitis B. One patient had a positive test for HBSAg by the radioimmunoassay technique only at the time leukemia was diagnosed; this patient had received transfusions some years before. In six patients icteric hepatitis B developed; five recovered completely and one died of leukemia during the course of hepatitis. All patients in whom hepatitis developed had received transfusions as a part of supportive therapy for leukemia. The hepatitis risk for patients who received transfusions of blood found to be negative for HBSAg by counterimmunoelectrophoresis was 0.26 percent per unit of blood administered.
58例成年急性白血病患者在疾病初发时检测血清中的乙肝抗原（HBSAg），并在病程中监测乙肝的发生情况。1例患者仅在白血病确诊时经放射免疫测定技术检测HBSAg呈阳性；该患者数年前曾接受过输血。6例患者发生黄疸型乙型肝炎；5例完全康复，1例在肝炎病程中死于白血病。所有发生肝炎的患者均接受过输血，作为白血病支持治疗的一部分。通过对流免疫电泳检测发现HBSAg呈阴性的输血患者，每输入一个单位血液的肝炎风险为0.26%。
