Eschenbach C, Schmitz-Moormann P, Gutjahr P
Helv Paediatr Acta. 1980 Dec;35(6):577-84.
The case history of a boy suffering from acute lymphoblastic leukemia (ALL) and carcinoma of the liver as secondary malignoma is reported. After completion of the combined ALL-therapy, a splenogenous thrombocytopenia emerged which was successfully treated by splenectomy. In the biopsy material liver cirrhosis and HBsAg-positive hepatitis could be detected; these proved to be progressive in the course of the following year. At the end of another year, a hepatocellular carcinoma was diagnosed, causing the patient's death, who was still in complete hematological remission 5 7/12 years after the onset and 2 9/12 years after the end of the ALL-therapy. Only two cases of hepatocellular carcinoma following ALL in childhood have been described in the literature so far.
报告了一名患有急性淋巴细胞白血病（ALL）并继发肝癌（作为继发性恶性肿瘤）的男孩的病例史。在完成ALL联合治疗后，出现了脾源性血小板减少症，通过脾切除术成功治疗。在活检材料中检测到肝硬化和HBsAg阳性肝炎；在接下来的一年中，这些病变被证明在进展。又过了一年年底，诊断出肝细胞癌，导致患者死亡，该患者在发病后5 7/12年以及ALL治疗结束后2 9/12年仍处于完全血液学缓解状态。迄今为止，文献中仅描述了两例儿童ALL后发生肝细胞癌的病例。
