Möschl P, Lubec G, Keiler A, Kreuzer W
Wien Med Wochenschr. 1979 Jan 15;129(1):24-6.
In 41 patients with benignant and malignant diseases of the stomach the appearance of alpha 1-acid glycoprotein (alpha1sGP) in the gastric juice was recorded quantitatively by radial immunodiffusion and compared with normal serum alpha1sGP by immunelectrophoretic analyzation and by immunodiffusion after after Ouchterlony. In 80.0% of the patients with carcinoma, in 11.8% of patients with gastric or duodenal ulcer and in 28.6% of the patients with gastritis the presence of alpha1sGP could be evidenced in the gastric juice. The appearance of this glycoprotein significantly differed in benignant and malignant diseases of the stomach. A polymorphism of the stomach alpha1sGP compared with normal serum alpha1sGP could not be established by the applied methods. Therefore it is unprobable that the gastric alpha1sGP is originated by the malignoma.
对41例患有胃部良性和恶性疾病的患者，采用放射免疫扩散法定量记录胃液中α1 - 酸性糖蛋白（α1sGP）的出现情况，并通过免疫电泳分析以及奥克特洛尼免疫扩散法，将其与正常血清α1sGP进行比较。在80.0%的胃癌患者、11.8%的胃或十二指肠溃疡患者以及28.6%的胃炎患者的胃液中可检测到α1sGP的存在。这种糖蛋白在胃部良性和恶性疾病中的出现情况存在显著差异。通过所应用的方法，未能确定胃α1sGP与正常血清α1sGP相比存在多态性。因此，胃α1sGP由恶性肿瘤产生的可能性不大。
