Sander P, Happe M, Stücker M, Hermes N, Hoffmann K, Altmeyer P
Dermatologische Klinik der Ruhr-Universität, Bochum im St.Josef-Hospital, Bochum.
Hautarzt. 1999 Oct;50(10):723-7. doi: 10.1007/s001050051057.
We examined whether it is possible to increase the antipsoriatic action by combining dithranol with a retinoid (tazarotene). In a randomized, open, prospective study with 50 psoriatic patients (22 females, 28 males, PASI>10) the antipsoriatic effectiveness of dithranol monotherapy to was compared combined therapy with dithranol and retinoid. The combination dithranol/retinoid (collective 2, reduction of the PASI from 17,2 to 2,8) revealed a significantly faster healing than the dithranol monotherapy (collective 1, reduction of the PASI from 18,5 to 4,8). The irritation of the combination therapy as evaluated with clinical score and laser doppler imaging was increased. Anti-psoriatic effectiveness of dithranol can be increased by combining it with tazarotene.
我们研究了将地蒽酚与一种维甲酸（他扎罗汀）联合使用是否有可能增强抗银屑病作用。在一项针对50例银屑病患者（22名女性，28名男性，PASI>10）的随机、开放、前瞻性研究中，比较了地蒽酚单一疗法与地蒽酚和维甲酸联合疗法的抗银屑病效果。地蒽酚/维甲酸联合使用（第2组，PASI从17.2降至2.8）显示出比地蒽酚单一疗法（第1组，PASI从18.5降至4.8）愈合速度明显更快。根据临床评分和激光多普勒成像评估，联合疗法的刺激性增加。地蒽酚与他扎罗汀联合使用可增强其抗银屑病效果。
