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An adenosine A3 receptor-selective agonist does not modulate calcium-activated potassium currents in hippocampal CA1 pyramidal neurons.

作者信息

Dunwiddie T V, Jacobson K A, Diao L

机构信息

Neuroscience Program, University of Colorado Health Sciences Center, Denver, USA.

出版信息

Prog Brain Res. 1999;120:275-85. doi: 10.1016/s0079-6123(08)63562-1.

DOI:10.1016/s0079-6123(08)63562-1
PMID:10551004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3449169/
Abstract
摘要

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2
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3
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A1 adenosine receptors differentially regulate the N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated components of hippocampal excitatory postsynaptic current in a Ca2+/Mg(2+)-dependent manner.A1 腺苷受体以Ca2+/Mg(2+) 依赖的方式差异性地调节海马兴奋性突触后电流中由N-甲基-D-天冬氨酸受体和非N-甲基-D-天冬氨酸受体介导的成分。
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本文引用的文献

1
A-adenosine receptors: design of selective ligands and therapeutic prospects.A 型腺苷受体：选择性配体的设计与治疗前景
Drugs Future. 1995 Jul;20(7):689-699. doi: 10.1358/dof.1995.020.07.531583.
2
Protein kinase C and A3 adenosine receptor activation inhibit presynaptic metabotropic glutamate receptor (mGluR) function and uncouple mGluRs from GTP-binding proteins.蛋白激酶C和A3腺苷受体激活可抑制突触前代谢型谷氨酸受体（mGluR）功能，并使mGluR与GTP结合蛋白解偶联。
J Neurosci. 1998 Aug 15;18(16):6138-46. doi: 10.1523/JNEUROSCI.18-16-06138.1998.
3
An A3-subtype adenosine receptor is highly expressed in rat vascular smooth muscle cells: its role in attenuating adenosine-induced increase in cAMP.A3亚型腺苷受体在大鼠血管平滑肌细胞中高表达：其在减弱腺苷诱导的环磷酸腺苷（cAMP）增加中的作用。
Microvasc Res. 1997 Nov;54(3):243-52. doi: 10.1006/mvre.1997.2044.
4
Adenosine A3 receptors potentiate hippocampal calcium current by a PKA-dependent/PKC-independent pathway.腺苷 A3 受体通过依赖蛋白激酶 A/不依赖蛋白激酶 C 的途径增强海马体钙电流。
Neuropharmacology. 1997 Mar;36(3):353-62. doi: 10.1016/s0028-3908(97)83762-8.
5
Selective activation of A3 adenosine receptors with N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits.用N6-(3-碘苄基)腺苷-5'-N-甲基脲苷选择性激活A3腺苷受体可保护清醒兔免受心肌顿抑和梗死，且不伴有血流动力学改变。
Circ Res. 1997 Jun;80(6):800-9. doi: 10.1161/01.res.80.6.800.
6
Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus.海马腺苷A3受体的激活会导致大鼠海马中A1受体介导的反应脱敏。
J Neurosci. 1997 Jan 15;17(2):607-14. doi: 10.1523/JNEUROSCI.17-02-00607.1997.
7
Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons.与肌醇三磷酸（IP3）生成偶联的代谢型谷氨酸受体介导大鼠齿状颗粒神经元中IAHP的抑制。
J Neurophysiol. 1996 Oct;76(4):2691-700. doi: 10.1152/jn.1996.76.4.2691.
8
G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain.大鼠脑中腺苷A3受体通过G蛋白依赖性激活磷脂酶C
Mol Pharmacol. 1995 Dec;48(6):1038-45.
9
Whole-cell voltage-clamp investigation of the role of PKC in muscarinic inhibition of IAHP in rat CA1 hippocampal neurons.全细胞电压钳研究蛋白激酶C在毒蕈碱对大鼠CA1海马神经元IAHP抑制作用中的角色。
Hippocampus. 1996;6(2):183-91. doi: 10.1002/(SICI)1098-1063(1996)6:2<183::AID-HIPO8>3.0.CO;2-Q.
10
The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells.A3 腺苷受体是唯一能促进肥大细胞释放过敏介质的腺苷受体。
J Biol Chem. 1993 Aug 15;268(23):16887-90.