Moskowitz G D, Shaffer T H, Dubin S E
Med Instrum. 1975 Jan-Feb;9(1):28-33.
Experimental results of in vivo animal tests conducted on a demand-regulated liquid breathing system are presented. When a liquid replaces gas as the medium in which oxygen and carbon dioxide are transported, several problems not typical in gas respiration occur. The increased mass and viscosity of a liquid as compared with a gas necessitate some means of mechanical assistance. The lower diffusion rates of gases in liquids as compared with gas rates places several constraints on the design of a mechanically assisted liquid breathing system. The liquid breathing system reported in this study has been designed to be demand-regulated, i.e., the animal has control over cycling the pumps which mechanically assist the circulation of an oxygenated liquid to and from the lungs. This system consists of a gas-operated diaphragm pump, demand controller, liquid regenerator with heater and gas scrubber, and ancillary equipment. A demand controller is described which obtains a control signal from an esophageal balloon catheter in the animal and governs operation of the pneumatically driven diaphragm pump.
本文介绍了对按需调节液体通气系统进行的体内动物试验的实验结果。当液体取代气体作为运输氧气和二氧化碳的介质时，会出现一些气体呼吸中不常见的问题。与气体相比，液体的质量和粘度增加，因此需要某种机械辅助手段。与气体速率相比，气体在液体中的扩散速率较低，这对机械辅助液体通气系统的设计提出了一些限制。本研究中报道的液体通气系统设计为按需调节，即动物可以控制泵的循环，这些泵机械辅助含氧液体在肺部的进出循环。该系统由气动隔膜泵、需求控制器、带加热器的液体再生器和气体洗涤器以及辅助设备组成。文中描述了一种需求控制器，它从动物体内的食管气囊导管获取控制信号，并控制气动驱动隔膜泵的运行。
