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[熊去氧胆酸治疗妊娠期肝内胆汁淤积症]

[Intrahepatic cholestasis in pregnancy treated with ursodeoxycholic acid].

作者信息

Grønlund L A

机构信息

Gynaekologisk-obstetrisk afdeling G, Amtssygehuset i Herlev.

出版信息

Ugeskr Laeger. 1999 Sep 27;161(39):5433-4.

Abstract

Intrahepatic cholestasis of pregnancy is characterized by pruritus and raised maternal aminotransferases and bile acid in serum. It is correlated to increased risk of meconium staining of amniotic fluid, stillbirth and premature labour. A case of treatment with ursodeoxycholic acid from 26. to 36. week gestation is described. Ursodeoxycholic acid is an effective treatment of intrahepatic cholestasis of pregnancy, but the effect seems to decrease after a period.

摘要

妊娠期肝内胆汁淤积症的特征为瘙痒以及母体血清转氨酶和胆汁酸升高。它与羊水胎粪污染、死产和早产风险增加相关。本文描述了一例在妊娠26至36周期间使用熊去氧胆酸进行治疗的病例。熊去氧胆酸是治疗妊娠期肝内胆汁淤积症的有效药物,但一段时间后效果似乎会降低。

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