Zittoun R, Bouchard M, Facquet-Danis J, Diaz-Mayo C, Percie-du-Sert M, Bousser J
Nouv Presse Med. 1975 Feb 8;4(6):401-4.
The in vitro sensitivity of leukemic cells to cytotoxic drugs was assessed in 61 cases of acute leukemia in adults, 49 of them were of the no lymphoblastic type and in the first phase of the disease. The depression of the incorporation of 14-C-thymidine and 3-H-uridine after a two hours incubation with the various cytotoxic drugs was compared with the clinical result obtained with two of them There is a significant correlation between the in vitro depression of the incorporation of 14-C-thymidine and the clinical effect of the drugs. This method, which may be utilized also in solid tumors, allows to predict with some accuracy the effect of chemotherapy, and to select between the various cytotoxic drugs. However the failure of a chemotherapy is generally related to an in vitro insensitivity of the malignant cells to almost all drugs.
对61例成人急性白血病患者的白血病细胞进行了体外细胞毒性药物敏感性评估，其中49例为非淋巴细胞型且处于疾病的第一阶段。将各种细胞毒性药物孵育两小时后14-C-胸腺嘧啶核苷和3-H-尿苷掺入量的降低情况与其中两种药物的临床结果进行了比较。14-C-胸腺嘧啶核苷掺入量的体外降低与药物的临床效果之间存在显著相关性。这种方法也可用于实体瘤，能较为准确地预测化疗效果，并在各种细胞毒性药物之间进行选择。然而，化疗失败通常与恶性细胞对几乎所有药物的体外不敏感性有关。
