Ganapathy S, Wasserman R A, Watson J T, Bennett J, Armstrong K P, Stockall C A, Chess D G, MacDonald C
Department of Anesthesia, London Health Sciences Center, University of Western Ontario, Canada.
Anesth Analg. 1999 Nov;89(5):1197-202.
We prospectively studied the continuous "modified" femoral three-in-one block for postoperative pain after total knee arthroplasty. Sixty-two patients undergoing elective knee arthroplasty under spinal anesthesia with bupivacaine (B) and fentanyl were randomized to receive 0.2% B, 0.1% B, or placebo at 10 mL/h for 48 h after an initial bolus of 30 mL of the same solution via the femoral block catheter. The catheters were inserted under the fascia iliaca using a "double pop" technique and a peripheral nerve stimulator and were advanced 15-20 cm cranially. Venous plasma levels of B, desbutylbupivacaine, and 4-hydroxy B were measured daily for 3 days. All patients received patient-controlled analgesia with morphine and indomethacin suppositories for 48 h. Using computed tomography, we evaluated the catheter location for 20 patients. The catheter tips, located superior to the upper third of the sacroiliac joint in the psoas sheath, were labeled as ideally located. The group receiving 0.2% B had a larger block success rate, smaller morphine consumption in the immediate postoperative period (15 vs 22 mg) and during the first postoperative day (9 vs 18 mg), and achieved a greater range of motion in the immediate postoperative period (91 degrees +/- 10 degrees vs 80 degrees + 13 degrees ). Visual analog scores for pain during both rest and activity were low but similar between the groups. Forty percent of the catheters evaluated were ideally located. Ideal location and use of 0.2% B resulted in 100% success of blockade of all three nerves. The S1 root was blocked in up to 76% of patients. The plasma levels of B, 4-hydroxy B, and desbutylbupivacaine were below the toxic range during the infusion. We conclude that continuous fascia iliaca block with 0.2% B results in opioid-sparing and improved range of motion during the immediate postoperative period. Larger doses of bupivacaine may safely be used in the immediate postoperative period if needed.
Continuous fascia iliaca block with 0.2% bupivacaine reduces opioid requirements and improves range of motion in the immediate postoperative period compared with a placebo and 0.1% bupivacaine. Plasma levels are below the toxic range with this dose. Only 40% of the catheters are positioned in the ideal location. With the smaller dose of bupivacaine, the success rate with this block is small.
我们前瞻性地研究了全膝关节置换术后持续“改良”股神经三合一阻滞用于术后镇痛。62例在布比卡因(B)和芬太尼腰麻下行择期膝关节置换术的患者,通过股神经阻滞导管给予30 mL初始推注相同溶液后,随机分为三组,分别以10 mL/h的速度持续输注0.2% B、0.1% B或安慰剂,共48小时。采用“双噗”技术和外周神经刺激器在髂筋膜下插入导管,并向头侧推进15 - 20 cm。连续3天每日测定静脉血浆中B、去丁基布比卡因和4 - 羟基B的水平。所有患者均接受吗啡患者自控镇痛和吲哚美辛栓剂治疗48小时。我们对20例患者进行计算机断层扫描评估导管位置。导管尖端位于腰大肌鞘内骶髂关节上三分之一上方被标记为理想位置。接受0.2% B组的阻滞成功率更高,术后即刻(15 mg对22 mg)和术后第1天(9 mg对18 mg)吗啡用量更少,术后即刻活动范围更大(91°±10°对80° + 13°)。休息和活动时的视觉模拟疼痛评分较低,但各组之间相似。评估的导管中有40%位置理想。理想位置及使用0.2% B导致所有三条神经阻滞成功率达100%。高达76%的患者S1神经根被阻滞。输注期间B、4 - 羟基B和去丁基布比卡因的血浆水平低于中毒范围。我们得出结论,0.2% B持续髂筋膜阻滞可减少阿片类药物用量,并在术后即刻改善活动范围。如有需要,术后即刻可安全使用更大剂量的布比卡因。
与安慰剂和0.1%布比卡因相比,0.2%布比卡因持续髂筋膜阻滞可减少阿片类药物需求,并在术后即刻改善活动范围。此剂量下血浆水平低于中毒范围。仅40%的导管位于理想位置。使用较小剂量布比卡因时,该阻滞的成功率较低。