Arai T, Takano Y, Mizukami S, Sato I
Department of Anesthesiology, Koshigaya Hospital, Dokkyo University, School of Medicine.
Masui. 1999 Oct;48(10):1083-90.
Plasma concentrations and hemodynamic effects of olprinone were evaluated in seventeen patients undergoing open heart surgery. The patients were randomized into the bolus group (15 micrograms.kg-1 bolus dose +0.1 microgram.kg-1.min-1 infusion, n = 9) and the non-bolus group (0.1 microgram.kg-1.min-1 infusion, n = 8). Plasma concentrations and hemodynamic variables were measured before CPB (cardiopulmonary bypass; baseline), 5, 60 min after weaning from CPB, and 3, 6 hours after the end of surgery. Plasma concentrations in the non-bolus group were significantly lower than those of bolus group at any point except for 3 hours after the end of surgery. In the bolus group, increases in the cardiac index and stroke volume index were significantly higher compared with the non-bolus group. From these results we conclude that olprinone given in bolus (15 micrograms.kg-1) followed by continuous infusion (0.1 microgram.kg-1.min-1) is efficacious and safe during weaning from CPB.
对17例接受心脏直视手术的患者评估了奥普力农的血浆浓度和血流动力学效应。患者被随机分为推注组（15微克·千克-1推注剂量+0.1微克·千克-1·分钟-1输注，n = 9）和非推注组（0.1微克·千克-1·分钟-1输注，n = 8）。在体外循环（CPB；心肺转流）前（基线）、脱离CPB后5、60分钟以及手术结束后3、6小时测量血浆浓度和血流动力学变量。除手术结束后3小时外，非推注组在任何时间点的血浆浓度均显著低于推注组。在推注组中，心脏指数和每搏量指数的增加显著高于非推注组。从这些结果我们得出结论，在脱离CPB期间，先给予15微克·千克-1推注剂量的奥普力农，随后持续输注（0.1微克·千克-1·分钟-1）是有效且安全的。
