Metformin structure and mechanisms of action were presented. Metformin plays a particularly important role in the treatment of diabetes mellitus type 2 by decreasing insulin resistance. Indications of its use include diabetes mellitus type 2 in obese patients without systemic complications or disordered blood supply in large body areas. It may be used as a monotherapy or combined with other oral drugs.
介绍了二甲双胍的结构和作用机制。二甲双胍通过降低胰岛素抵抗在2型糖尿病治疗中发挥着尤为重要的作用。其适用症包括无全身并发症或大面积身体部位血液供应紊乱的肥胖患者的2型糖尿病。它可作为单一疗法使用,也可与其他口服药物联合使用。