Sokup A, Swiatkowski M
Katedry i Kliniki Gastroenterologii i Chorób Wewnetrznych Akademii Medycznej im L. Rydygiera w Bydgoszczy.
Przegl Lek. 1999;56(5):347-50.
The metabolic changes in carbohydrate metabolism lead to steadily increasing of insulin resistance during normal pregnancy. In women with abnormality of carbohydrate metabolism it may cause glucose intolerance defined as gestational diabetes and complicating in 3-5% of all pregnancies. Women with previous history of gestational diabetes are at risk for the later development of diabetes mellitus. Despite many different studies etiopathogenesis of gestational diabetes is still unknown. Increase of placenta hormones, beta cell dysfunction and insulin-resistance are involved in pathogenesis of gestational diabetes. Last observations suggest the new potential pathogenic factors such as: cellular membrane ATP-ase and structure dysfunction changes, lipotoxicity on pancreatic beta cell, increase secretion of islet amyloid polypeptide and genetic defects.
正常妊娠期间碳水化合物代谢的变化会导致胰岛素抵抗持续增加。在碳水化合物代谢异常的女性中，这可能会导致葡萄糖不耐受，即妊娠期糖尿病，在所有妊娠中占3-5%。有妊娠期糖尿病病史的女性日后患糖尿病的风险较高。尽管有许多不同的研究，但妊娠期糖尿病的病因仍不清楚。胎盘激素增加、β细胞功能障碍和胰岛素抵抗都参与了妊娠期糖尿病的发病机制。最近的观察结果表明了一些新的潜在致病因素，如：细胞膜ATP酶和结构功能障碍变化、胰腺β细胞的脂毒性、胰岛淀粉样多肽分泌增加以及遗传缺陷。
