Conformational aspects of human formylpeptide receptor antagonists.
作者信息
Scatturin A, Vertuani G, Pecoraro R, Dalpiaz A, Boggian M, Ferretti M E, Spisani S
机构信息
Department of Pharmaceutical Sciences, Ferrara University, Italy.
出版信息
Arzneimittelforschung. 1999 Oct;49(10):873-7. doi: 10.1055/s-0031-1300519.
PMID:10554666
Abstract
The conformation of several Phe-D-Leu-Phe-D-Leu-Phe analogues was analyzed using infrared absorption and circular dichroism. Their effect on human neutrophils was verified by receptor binding and chemotaxis assays. The results demonstrate that the compounds examined prefer an ordered conformation (beta-turn) in amphipatic environment, and that they are able to antagonize the neutrophil functions evoked by CHO-Met-Leu-Phe.
摘要
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