分泌成分（SC）和J链在IgA腺泡转运中作用的进一步证据。

Further evidence for a role of secretory component (SC) and J chain in the glandular transport of IgA.

作者信息

Brandtzaeg P, Savilahti E

出版信息

Adv Exp Med Biol. 1978;107:219-26. doi: 10.1007/978-1-4684-3369-2_26.

Abstract

These studies support the transport model depicted in Figure 3: Incorporation of J chains into dimeric IgA induces a configurational fit allowing complexing of IgA with SC available in the plasma membrane of serous secretory epithelial cells. This complexing on the surface of the cell stimulates pinocytosis, and the completed secretory IgA molecules are transported in cytoplasmic vesicles to the gland lumen. The same transport model can be applied for the external translocation of IgM.

摘要

这些研究支持图3所示的转运模型：J链掺入二聚体IgA诱导构象匹配，使IgA与浆液分泌上皮细胞质膜中可用的分泌片（SC）形成复合物。细胞表面的这种复合刺激胞饮作用，完整的分泌型IgA分子在细胞质小泡中被转运至腺腔。相同的转运模型可应用于IgM的外向转运。