Pfeffer S R
Department of Biochemistry, Stanford University School of Medicine, California 94305-5307, USA.
Nat Cell Biol. 1999 May;1(1):E17-22. doi: 10.1038/8967.
Protein secretion and the transport of proteins between membrane-bound compartments are mediated by small, membrane-bound vesicles. Here I review what is known about the process by which vesicles are targeted to the correct destination. A growing family of proteins, whose precise modes of action are far from established, is involved in targeting. Despite the wide diversity in the identities of the players, some common themes are emerging that may explain how vesicles can identify their targets and release their cargo at the correct time and place in eukaryotic cells.
蛋白质分泌以及蛋白质在膜结合区室之间的运输是由小的膜结合囊泡介导的。在此，我将综述关于囊泡靶向正确目的地的过程的已知信息。一个不断增加的蛋白质家族参与了靶向过程，其精确作用模式远未明确。尽管参与其中的成分具有广泛的多样性，但一些共同的主题正在浮现，这可能解释了在真核细胞中囊泡如何识别其靶标并在正确的时间和地点释放其货物。
