Nagler R M, Sherman Y, Nagler A
Department of Oral and Maxillofacial Surgery, Rambam Medical Centre, Haifa, Israel.
J Clin Pathol. 1999 May;52(5):395-7. doi: 10.1136/jcp.52.5.395.
Major salivary gland dysfunction and severe xerostomia is one of the manifestations of graft versus host disease (GVHD). The histopathological evaluation of the major salivary gland in patients with GVHD has never been reported. The pathological findings of the submandibular glands in a GVHD patient who succumbed to the disease are described. Lymphocytic infiltration, parenchymal destruction, and fibrosis were observed, which may provide the pathophysiological mechanism for the xerostomia and hyposalivation observed in GVHD.
主要唾液腺功能障碍和严重口干是移植物抗宿主病（GVHD）的表现之一。关于GVHD患者主要唾液腺的组织病理学评估从未有过报道。本文描述了一名死于GVHD患者下颌下腺的病理发现。观察到淋巴细胞浸润、实质破坏和纤维化，这可能为GVHD中观察到的口干和唾液分泌减少提供病理生理机制。
