Tozer M J, Buck I M, Cooke T, Kalindjian S B, McDonald I M, Pether M J, Steel K I
The James Black Foundation, London, UK.
Bioorg Med Chem Lett. 1999 Nov 1;9(21):3103-8. doi: 10.1016/s0960-894x(99)00535-1.
4-Chlorophenylmethanesulfonamide and (4-chlorobenzyl)sulfamide derivatives of histamine homologues were prepared and found to be potent and selective histamine H3 receptor antagonists. High receptor affinity and low differences in the data from the bioassays were achieved with the imidazol-4-ylbutyl analogues.
制备了组胺同系物的4-氯苯基甲磺酰胺和（4-氯苄基）磺酰胺衍生物，发现它们是强效且选择性的组胺H3受体拮抗剂。咪唑-4-基丁基类似物实现了高受体亲和力和生物测定数据中的低差异。
