Schlaeper C, Amerling R, Manns M, Levin N W
Fresenius Medical Care, Lexington, Massachusetts 02420, USA.
Kidney Int Suppl. 1999 Nov(72):S20-3.
Recent studies suggest that the dialysis dose significantly affects survival in acute renal failure (ARF) patients and that bicarbonate dialysate improves acid-base balance during continuous renal replacement therapy (CRRT). These data inspired us to use slow continuous dialysis (SCD) in the treatment of ARF. SCD is defined by the following parameters: (a) blood flow (Q(B)) = 100 to 200 ml/min, (b) dialysate flow (Q(D)) = 100 to 300 ml/min, (c) the use of a modified hemodialysis machine with controlled ultrafiltration and online production of bicarbonate-based dialysate, and (d) continuous or extended daily treatment for 8 to 24 hours. SCD provides a urea clearance in the 70 to 80 ml/min range. Preliminary data from an ongoing clinical trial demonstrate the safety, efficiency, and simplicity of the treatment.
近期研究表明，透析剂量对急性肾衰竭（ARF）患者的生存率有显著影响，并且在持续肾脏替代治疗（CRRT）期间，碳酸氢盐透析液可改善酸碱平衡。这些数据促使我们采用缓慢持续透析（SCD）治疗ARF。SCD由以下参数定义：（a）血流量（Q(B)）=100至200毫升/分钟，（b）透析液流量（Q(D)）=100至300毫升/分钟，（c）使用具有可控超滤和在线生产碳酸氢盐透析液功能的改良血液透析机，以及（d）持续或每日延长治疗8至24小时。SCD的尿素清除率在70至80毫升/分钟范围内。一项正在进行的临床试验的初步数据证明了该治疗方法的安全性、有效性和简便性。
