环孢素在一名患有他克莫司相关溶血性尿毒症综合征的肺移植受者中的成功应用。

Successful use of cyclosporine in a lung transplant recipient with tacrolimus-associated hemolytic uremic syndrome.

作者信息

Myers J N, Shabshab S F, Burton N A, Nathan S D

机构信息

Division of Pulmonary/Critical Care Medicine, National Naval Medical Center, Bethesda, Maryland 20889-5600, USA.

出版信息

J Heart Lung Transplant. 1999 Oct;18(10):1024-6. doi: 10.1016/s1053-2498(99)00056-x.

DOI:10.1016/s1053-2498(99)00056-x

PMID:10561115

Abstract

Hemolytic-uremic syndrome (HUS) is a rare, but well-described complication in organ transplant recipients maintained on cyclosporine immunosuppression. Tacrolimus is a newer agent with similar immunosuppressant efficacy. In cases of cyclosporine-related HUS in renal transplant recipients, tacrolimus has been used successfully without recurrence of HUS. Tacrolimus has been reported to cause HUS in renal and more recently in cardiac transplant patients. We report a case of HUS in a lung transplant recipient receiving tacrolimus who was subsequently converted to cyclosporine without recurrence of HUS.

摘要

溶血尿毒综合征（HUS）是接受环孢素免疫抑制治疗的器官移植受者中一种罕见但已被充分描述的并发症。他克莫司是一种具有相似免疫抑制功效的新型药物。在肾移植受者发生与环孢素相关的HUS病例中，使用他克莫司成功治疗且HUS未复发。据报道，他克莫司可导致肾移植患者发生HUS，最近也有心脏移植患者发生HUS的报道。我们报告一例接受他克莫司治疗的肺移植受者发生HUS的病例，该患者随后转换为环孢素治疗，HUS未复发。