Park Moo Suk
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
J Chest Surg. 2022 Aug 5;55(4):338-356. doi: 10.5090/jcs.22.066.
Lung transplantation (LT) is now considered as an effective treatment option for end-stage lung diseases that improves the short and long-term survival rates and quality of life. As increasingly many LT procedures are being performed, the medical complications of LT are also increasing in frequency and emerging as a very important issue for transplant clinicians. Although chronic lung allograft dysfunction and infection are major causes of death after LT, many medical complications, several of which result from immunosuppressive treatment, contribute to increased mortality and morbidity. This article reviews the most frequent and important medical complications of LT, accompanied by a review of the literature and studies from South Korea, including lung allograft rejection, infection, and non-allograft organ systemic complications.
肺移植(LT)现在被认为是治疗终末期肺部疾病的一种有效选择,它能提高短期和长期生存率以及生活质量。随着越来越多的肺移植手术得以开展,肺移植的医学并发症在频率上也不断增加,并成为移植临床医生面临的一个非常重要的问题。尽管慢性肺移植功能障碍和感染是肺移植术后死亡的主要原因,但许多医学并发症(其中一些是由免疫抑制治疗导致的)导致了死亡率和发病率的上升。本文回顾了肺移植最常见且重要的医学并发症,并对包括韩国在内的相关文献和研究进行了综述,内容涵盖肺移植排斥反应、感染以及非移植器官的全身并发症。