Walther E U, Hohlfeld R
Department of Neurology and Institute for Clinical Neuroimmunology, Munich, Germany.
Neurology. 1999 Nov 10;53(8):1622-7. doi: 10.1212/wnl.53.8.1622.
Article abstract-Interferon beta (IFNbeta) reduces the relapse rate, disease activity as measured by serial MRI scanning, and disease progression of MS. Therapy with IFNbeta may be associated with a number of adverse reactions. Relatively frequent side effects include flu-like symptoms, transient laboratory abnormalities, menstrual disorders, and increased spasticity. Dermal injection site reactions occur after subcutaneous application of IFNbeta-1b and IFNbeta-1a. Possible side effects of IFNbeta include various autoimmune reactions, capillary leak syndrome, anaphylactic shock, thrombotic-thrombocytopenic purpura, insomnia, headache, alopecia, and depression. We discuss the mechanisms and management of the different side effects of IFNbeta.
文章摘要——β-干扰素（IFNβ）可降低复发率、通过系列磁共振成像扫描测量的疾病活动度以及多发性硬化症（MS）的疾病进展。IFNβ治疗可能与多种不良反应相关。相对常见的副作用包括流感样症状、短暂的实验室检查异常、月经紊乱以及痉挛加剧。皮下注射IFNβ-1b和IFNβ-1a后会出现皮肤注射部位反应。IFNβ的可能副作用包括各种自身免疫反应、毛细血管渗漏综合征、过敏性休克、血栓性血小板减少性紫癜、失眠、头痛、脱发和抑郁。我们讨论了IFNβ不同副作用的机制及处理方法。
