Rye D B, Johnston L H, Watts R L, Bliwise D L
Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Neurology. 1999 Nov 10;53(8):1868-70. doi: 10.1212/wnl.53.8.1868.
We describe an unmedicated patient with juvenile PD with difficulties maintaining wakefulness and the atonia of REM sleep. Laboratory testing showed enhanced muscle activity in REM sleep consistent with a history of dream enactment behavior (i.e., REM sleep behavior disorder) and daytime sleepiness, and REM-sleep onsets on multiple sleep latency testing. The results emphasize the potential role of dopamine and basal ganglia circuits in the modulation of activated behavioral states (e.g., wakefulness and REM sleep).
我们描述了一名未接受药物治疗的青少年帕金森病患者，该患者难以维持清醒状态，且快速眼动（REM）睡眠期肌张力缺失。实验室检查显示，其REM睡眠期肌肉活动增强，这与既往的梦呓行为史（即REM睡眠行为障碍）及日间嗜睡情况相符，并且在多次睡眠潜伏期试验中出现了REM睡眠起始。这些结果强调了多巴胺和基底神经节回路在调节激活行为状态（如清醒和REM睡眠）中的潜在作用。
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