通过向preBötzinger复合体中产生节律的神经元输入肽能信号来调节呼吸频率。
Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex.
作者信息
Gray P A, Rekling J C, Bocchiaro C M, Feldman J L
机构信息
Department of Neurobiology, University of California Los Angeles, Box 951763, Los Angeles, CA 90095-1763, USA.
出版信息
Science. 1999 Nov 19;286(5444):1566-8. doi: 10.1126/science.286.5444.1566.
Abstract
Neurokinin-1 receptor (NK1R) and mu-opioid receptor (muOR) agonists affected respiratory rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBötC rhythmogenic neurons. The distribution of NK1R+ neurons anatomically defined the preBötC. Type 1 neurons in the preBötC, which have rhythmogenic properties, expressed both NK1Rs and muORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBötC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and muORs generate respiratory rhythm and modulate respiratory frequency.
摘要
当直接注射到前包钦格复合体（preBötC）时，神经激肽-1受体（NK1R）和μ-阿片受体（muOR）激动剂会影响呼吸节律，前包钦格复合体被认为是哺乳动物呼吸节律产生的部位。这些作用是通过对前包钦格复合体节律性神经元的作用介导的。NK1R阳性神经元的分布在解剖学上定义了前包钦格复合体。前包钦格复合体中具有节律生成特性的1型神经元同时表达NK1R和muOR，而2型神经元仅表达NK1R。这些发现表明，前包钦格复合体是一个具有独特生理功能的可定义解剖结构，并且同时表达NK1R和muOR的神经元亚群产生呼吸节律并调节呼吸频率。
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