Tulen J H, Azzolini M, de Vries J A, Groeneveld W H, Passchier J, van De Wetering B J
Department of Psychiatry, University Hospital Rotterdam, Dijkzigt and Erasmus University Rotterdam, Rotterdam, The Netherlands.
J Neurol Neurosurg Psychiatry. 1999 Dec;67(6):800-2. doi: 10.1136/jnnp.67.6.800.
Spontaneous eye blink rate and frequency of eye tics were studied in nine Tourette patients during periods of rest, conversation, and video watching. In comparison with controls, the Tourette patients showed a significantly higher blink rate during rest and video watching. Conversation induced a significant increase in blink rate in the control group, but not in the Tourette patients, whereas video watching significantly increased blink rate in both groups. The frequency of eye tics showed a significant decrease during conversation and increased significantly during video watching in Tourette patients. In five patients, a significant positive correlation between blink rate and eye tic frequency was found, whereas one patient showed a significant negative correlation. Our results show that, even though some of our patients were on neuroleptic treatment, blink rate was about twofold to threefold increased versus healthy controls, suggesting increased central dopaminergic activity. Furthermore, these first quantitative data illustrate task specific effects on eye tic frequency and the complexity of their relation with eye blinks.
在休息、交谈和观看视频期间，对9名图雷特综合征患者的自发眨眼率和眼部抽搐频率进行了研究。与对照组相比，图雷特综合征患者在休息和观看视频期间眨眼率显著更高。交谈使对照组的眨眼率显著增加，但图雷特综合征患者没有，而观看视频使两组的眨眼率均显著增加。图雷特综合征患者的眼部抽搐频率在交谈期间显著降低，在观看视频期间显著增加。在5名患者中，发现眨眼率与眼部抽搐频率之间存在显著正相关，而1名患者表现出显著负相关。我们的结果表明，尽管我们的一些患者正在接受抗精神病药物治疗，但与健康对照组相比，眨眼率增加了约两倍至三倍，这表明中枢多巴胺能活动增加。此外，这些首批定量数据说明了任务对眼部抽搐频率的特定影响以及它们与眨眼关系的复杂性。
