Vijayaraghavan K, Whitlock R I
Br J Oral Surg. 1975 Jul;13(1):64-72. doi: 10.1016/0007-117x(75)90024-4.
An unusual case of hemorrhagic bone cyst observed over a period of 12 years is presented. The diagnosis was confirmed by surgical exploration and histological examination of the tissue. The lesion continued to expand in spite of repeated surgical mandible. Finally, bone formation obliterated the cavity completely at the age of 19, when the facial deformity was corrected. It is suggested that this hemorrhagic bone cyst is of developmental origin. Since intramedullary haemorrhage and proliferation of giant cells are both responsible for the cavity formation and expansion, it is possible that aberrant formation of giant cells by fusion of endothelial cells of abnormal blood vessels may be an important factor in the pathogenesis of this condition.
本文报告了一例观察12年的罕见出血性骨囊肿病例。通过手术探查和组织学检查确诊。尽管多次对下颌骨进行手术，病变仍持续扩大。最终，在19岁面部畸形得到矫正时，骨形成完全闭塞了腔隙。提示该出血性骨囊肿起源于发育异常。由于髓内出血和巨细胞增殖均与腔隙形成和扩大有关，异常血管内皮细胞融合形成巨细胞的异常过程可能是本病发病机制中的一个重要因素。
