Malaguarnera M, Di Fazio I, Vinci E, Bentivegna P, Mangione G, Romano M
Department of Internal Medicine and Geriatrics, University of Catania.
Panminerva Med. 1999 Sep;41(3):227-31.
A more prolonged life expectancy is associated with an increased morbidity rate with marked alterations of physiologic and metabolic functions in the body. The haematologic pattern can be modified during ageing because of reduced cellular replication and enhanced fibrosis in the bone marrow. Nevertheless it is not clear whether ageing represents the cause or the result of these phenomena.
In order to evaluate wide variation of data on the haematologic pattern in elderly subjects, we studied one hundred eight healthy subjects (27 males, 81 females; ranging from 50 to 99 years), living in their home.
We observed a reduction in serum iron and transferrin and an increase in serum ferritin levels during ageing, with a consequential iron tissue stores increase.
Our data suggested that senescence was associated with an increased incidence of anemia, which cannot be considered a normal feature of aging, the physicians must investigate each cause of anemia in elderly subjects. Haematological pattern is in the normal range in healthy elderly subjects, even if we found significant age-linked changes. We conclude that a progressive impairment of bone marrow functions is the most important factor in determining significant changes of hematopoiesis in healthy elderly subjects.
预期寿命延长与发病率增加相关，身体的生理和代谢功能会发生显著改变。由于细胞复制减少和骨髓纤维化增强，血液学模式在衰老过程中可能会发生改变。然而，尚不清楚衰老是这些现象的原因还是结果。
为了评估老年受试者血液学模式数据的广泛差异，我们研究了108名居住在家中的健康受试者（27名男性，81名女性；年龄在50至99岁之间）。
我们观察到衰老过程中血清铁和转铁蛋白降低，血清铁蛋白水平升高，从而导致铁组织储存增加。
我们的数据表明衰老与贫血发病率增加有关，贫血不能被视为衰老的正常特征，医生必须调查老年受试者贫血的每一个原因。即使我们发现了与年龄相关的显著变化，但健康老年受试者的血液学模式仍在正常范围内。我们得出结论，骨髓功能的渐进性损害是决定健康老年受试者造血功能发生显著变化的最重要因素。
