Ferlito S, Gallina M, Catassi S, Bisicchia A, Di Salvo M
Chair of Semeiology and Medical Methodology, University of Catania, Garibaldi Hospital, Italy.
Panminerva Med. 1999 Sep;41(3):239-42.
The authors studied the plasmatic levels of nitrites, stable end-products of nitric oxide in arteriopathic patients before and after vasoactive and lipid-lowering treatment.
The series consisted of 63 subjects (mean age 64 +/- 9) suffering from peripheral arterial occlusive disease; 21 subjects with total cholesterol (TC) lower than 200 mg/dl were considered as normolipemic (group A); 24 subjects with TC ranging between 200 and 240 mg/dl were considered as mild hypercholesterolemic (group B); 18 subjects with TC higher than 240 mg/dl were consider as severe hypercholesterolemic (group C). All the patients were examined before and after 15 and 30 days of a vasoactive treatment (calciparine, aspirin, buflomedil and pentoxiphylline); group B after vasoactive and diet (NCEP phase 1) treatment and group C after vasoactive, diet and drug (simvastatin) treatment. Nitrite plasma levels were determined by the Gutman and Hollywood colorimetric method.
In group A the basal value of nitrites was sharply (p < 0.05) lower than controls; after vasoactive treatment a significant increase (p < 0.05), was observed after 15 and 30 days; in group B the basal value was higher than controls; after 15 days a significant increase (p < 0.5) was noted, but a regression was found after 30 days. Also in group C the basal value of nitrites was higher (p < 0.05) than controls; after treatment significant changes were not found.
The increase of nitrites in group A may be due to an improved endothelial function; this phenomenon, less appreciable in group B and no longer evident in group C may depend on the lipid-lowering treatment.
作者研究了血管病变患者在进行血管活性治疗和降脂治疗前后血浆中亚硝酸盐（一氧化氮的稳定终产物）的水平。
该系列研究包括63名外周动脉闭塞性疾病患者（平均年龄64±9岁）；21名总胆固醇（TC）低于200mg/dl的患者被视为血脂正常（A组）；24名TC在200至240mg/dl之间的患者被视为轻度高胆固醇血症（B组）；18名TC高于240mg/dl的患者被视为重度高胆固醇血症（C组）。所有患者在进行15天和30天的血管活性治疗（钙泊三醇、阿司匹林、丁咯地尔和己酮可可碱）前后接受检查；B组在进行血管活性治疗和饮食（美国国家胆固醇教育计划第一阶段）治疗后，C组在进行血管活性治疗、饮食和药物（辛伐他汀）治疗后。采用古特曼和霍利迪比色法测定血浆亚硝酸盐水平。
A组亚硝酸盐的基础值显著低于对照组（p<0.05）；血管活性治疗后15天和30天观察到显著升高（p<0.05）；B组基础值高于对照组；15天后观察到显著升高（p<0.5），但30天后出现下降。C组亚硝酸盐的基础值也高于对照组（p<0.05）；治疗后未发现显著变化。
A组亚硝酸盐升高可能是由于内皮功能改善；这种现象在B组不太明显，在C组不再明显，可能取决于降脂治疗。
