Cantatore F P, Pipitone V
Department of Rheumatology, University of Bari, Italy.
Panminerva Med. 1999 Sep;41(3):247-51.
Osteoporosis is a condition in which an imbalance appears between bone resorption and formation, with bone resorption exceeding formation. However since the rate of bone loss varies significantly from one individual to another resulting in different degrees of osteoporosis, new biochemical techniques to measure products of bone resorption and bone formation have been used in the last years allowing us to evaluate the degree of bone turnover. Bone tissue is constituted of an inorganic component and an organic matrix of collagen and noncollagenous proteins. Suitable bone marker should report the formation and degradation of all these constituents. Today markers of bone formation and markers of bone resorption are available. According to recent literature and personal data assessment of bone metabolism by the specific biochemical markers is helpful to select osteoporotic patients with high or low bone turnover and these parameters should be used to evaluate whether bone remains sensitive to different therapies.
骨质疏松症是一种骨吸收与骨形成之间出现失衡，且骨吸收超过骨形成的病症。然而，由于个体之间的骨质流失速率差异显著，导致骨质疏松的程度各不相同，因此在过去几年中，人们采用了新的生化技术来测量骨吸收和骨形成的产物，从而使我们能够评估骨转换的程度。骨组织由无机成分以及胶原蛋白和非胶原蛋白的有机基质构成。合适的骨标志物应能反映所有这些成分的形成和降解情况。如今，骨形成标志物和骨吸收标志物均已存在。根据近期文献以及个人数据，通过特定生化标志物评估骨代谢有助于筛选出高骨转换或低骨转换的骨质疏松症患者，并且这些参数应用于评估骨骼对不同治疗方法是否仍保持敏感。
