de Leeuw P W, Peeters L L
Afd. Interne Geneeskunde, Academisch Ziekenhuis, Maastricht.
Ned Tijdschr Geneeskd. 1999 Oct 23;143(43):2131-2.
Even in an early phase of pregnancy marked haemodynamic changes occur, including a fall in vascular resistance and blood pressure and a rise in cardiac output. To compensate for the increased intravascular capacity the kidney retains more sodium and water. Apparently, the set point of sodium homeostasis shifts to a higher level at the expense of an expansion of extracellular volume. Studies during the normal menstrual cycle have shown that these changes, albeit smaller, also occur during the luteal phase. These fluctuations with the menstrual cycle are less apparent if salt intake is low, suggesting that a high salt intake is needed to facilitate the process of sodium retention. In pregnancies complicated by hypertension and/or pre-eclampsia body fluid volumes are low with an enhanced tendency to retain sodium after a volume challenge. These data, together with the lack of an apparent benefit of sodium restriction, suggest that the practice of prescribing a low-salt diet to hypertensive pregnant women should be abandoned.
即使在妊娠早期也会出现显著的血流动力学变化,包括血管阻力和血压下降以及心输出量增加。为了补偿血管内容量的增加,肾脏会保留更多的钠和水。显然,钠稳态的设定点会转移到更高水平,代价是细胞外液量增加。正常月经周期的研究表明,这些变化虽然较小,但在黄体期也会发生。如果盐摄入量低,这些随月经周期的波动就不太明显,这表明需要高盐摄入来促进钠潴留过程。在并发高血压和/或先兆子痫的妊娠中,体液量较低,在容量负荷后钠潴留的倾向增强。这些数据,再加上限制钠摄入没有明显益处,表明应该摒弃给高血压孕妇开低盐饮食处方的做法。