Calkins H
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Am J Cardiol. 1999 Oct 21;84(8A):20Q-25Q. doi: 10.1016/s0002-9149(99)00626-8.
Vasovagal syncope is a common disorder of autonomic cardiovascular regulation. Many pharmacologic agents have been proposed as effective in the management of this condition based on nonrandomized clinical trials. Notably, only 3 agents--atenolol, midodrine, and paroxetine--have demonstrated efficacy in the treatment of vasovagal syncope in at least 1 prospective, randomized, placebo-controlled clinical trial. Other therapies commonly used in treating syncope include increased salt and fluid intake and fludrocortisone. In this review, we provide a summary of currently available data that support or question the use of various pharmacologic agents for treatment of vasovagal syncope.
血管迷走性晕厥是自主神经心血管调节的一种常见病症。基于非随机临床试验，许多药物已被提出可有效治疗这种病症。值得注意的是，在至少1项前瞻性、随机、安慰剂对照临床试验中，只有3种药物——阿替洛尔、米多君和帕罗西汀——已证明对血管迷走性晕厥有治疗效果。治疗晕厥常用的其他疗法包括增加盐和液体摄入量以及使用氟氢可的松。在本综述中，我们总结了目前支持或质疑使用各种药物治疗血管迷走性晕厥的现有数据。
