Design, synthesis and DNA-cleavage of Gly-Gly-His-naphthalene diimide conjugates.
作者信息
Steullet V, Dixon D W
机构信息
Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta 30303, USA.
出版信息
Bioorg Med Chem Lett. 1999 Oct 18;9(20):2935-40. doi: 10.1016/s0960-894x(99)00505-3.
Abstract
Naphthalene diimides with one and two metal-chelating Gly-Gly-His (GGH) motifs have been synthesized. Both conjugates induce single-stranded cleavage of plasmid pBR322 DNA in the presence of nickel and Oxone and are approximately 100-fold more efficient than Ni(II) x GH-CONH2 itself.
摘要
Zotero 插件